Definition

Feline panleukopaenia (FPL), also known as feline infectious enteritis and feline parvovirus, is a serious viral disease caused by feline parvovirus (FPV). The name describes its primary effect: widespread destruction of circulating white blood cells (leukocytes), leaving the immune system severely compromised. The virus also attacks rapidly dividing cells in the bone marrow and the intestinal lining.

It is one of the most contagious feline diseases known and one of the most environmentally stable viruses — surviving on surfaces, bedding, soil, and hard floors for months to years. The WSAVA Vaccination Guidelines classify it as a core vaccine disease for all cats worldwide, regardless of lifestyle.

How it spreads

FPV spreads primarily through:

  • Direct contact with infected cats (most contagious during illness)
  • Contact with contaminated faeces, urine, vomit, or nasal secretions
  • Indirect contact via shared food bowls, bedding, litter boxes, and clothing — the virus is extremely stable on surfaces
  • Vertical transmission: infected pregnant queens can pass FPV to kittens in utero, causing cerebellar hypoplasia or stillbirth

Because FPV persists in the environment for so long, a home that has housed an infected cat can remain infectious for months even after thorough cleaning. Bleach at 1:32 dilution is one of the few household disinfectants that reliably inactivates the virus.

Signs

The incubation period is typically 2–7 days. Signs develop rapidly and can deteriorate within hours in kittens:

  • Sudden severe lethargy and depression
  • High fever (initially) followed by hypothermia as disease progresses
  • Vomiting — often bilious and persistent
  • Profuse, often bloody diarrhoea
  • Complete anorexia
  • Dehydration — sunk eyes, reduced skin turgor

Any unvaccinated kitten or cat showing rapid onset of these signs needs an emergency vet call. See our signs it is time to call the vet guide for the full emergency checklist.

Prevention

Vaccination is highly effective and provides durable immunity against FPV. Two kitten doses (at 8–9 weeks and 11–12 weeks) followed by a 12-month booster, then boosters every 3 years, provides reliable long-term protection. Full details of the kitten and adult vaccination schedule are in our cat vaccinations guide.

There is no specific antiviral treatment — management is supportive: intensive IV fluid therapy, antibiotics to prevent secondary bacterial infection, anti-nausea medication, and nutritional support. In kittens, even with aggressive treatment, survival is not guaranteed. Vaccination is the only reliable protection.